Procollagen 1 ? a marker of fibroblastic and fibrohistiocytic skin tumors
| Autor: | Kristian Rossen, Dorrit Krustrup, Henrik Klem Thomsen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Leiomyosarcoma
Desmoplastic melanoma medicine.medical_specialty Pathology Skin Neoplasms Histology integumentary system CD68 Cell CD34 Histiocytes Anatomical pathology Dermatology Fibroblasts Biology medicine.disease Immunohistochemistry Pathology and Forensic Medicine Procollagen peptidase medicine.anatomical_structure Biomarkers Tumor medicine Humans Procollagen |
| Zdroj: | Journal of Cutaneous Pathology. 33:614-618 |
| ISSN: | 1600-0560 0303-6987 |
| DOI: | 10.1111/j.1600-0560.2006.00484.x |
| Popis: | Background: When dealing with tumors of presumed fibroblastic or fibrohistiocytic origin, immunohistochemistry is traditionally done to exclude a tumor of non-fibroblastic or non-fibrohistiocytic nature, because a reliable marker of fibroblastic or fibrohistiocytic cell origin is still to be introduced. This study investigates whether procollagen 1 is a useful marker of skin tumors composed of cells derived from fibroblasts or fibrohistiocytes. Materials and methods: Twenty-nine different types of skin tumors, including tumors composed of spindle cells as well as some additional epithelial and melanocytic tumors, were stained immunohistochemically with antibodies against procollagen 1. The total number of cases tested was 154. Results: Tumors composed of cells of fibroblastic or fibrohistiocytic origin in general showed a high expression of procollagen 1, whereas tumors composed of non-fibroblastic cells in general showed no expression. However, there were a few exceptions, e.g., leiomyosarcoma and desmoplastic melanoma. Conclusions: The study suggests that immunohistochemical staining for procollagen 1 is a valuable marker for skin tumors composed of spindle cells derived from fibroblasts or fibrohistiocytes. However, in cases of spindle cell tumors with a morphology suggesting malignancy, it is recommended to use a panel of antibodies, which besides procollagen 1 includes markers such as S100, CD68, CD34, h-caldesmon, and pancytokeratin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|