Impact of Exercise on Susceptibility and Severity of COVID-19 in Patients with Cancer: A Retrospective Study

Autor: Joshua W. Bliss, Jessica A. Lavery, Whitney P. Underwood, Su S. Chun, Gina A. Fickera, Catherine P. Lee, Stacie Corcoran, Molly A. Maloy, Fernanda C. Polubriaginof, Daniel W. Kelly, Jessica M. Scott, Paul C. Boutros, Chaya S. Moskowitz, Lee W. Jones
Rok vydání: 2022
Předmět:
Zdroj: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol 31, iss 5
Cancer Epidemiol Biomarkers Prev
ISSN: 1538-7755
1055-9965
Popis: Background: Modifiable lifestyle-related factors heighten the risk and severity of coronavirus disease 2019 (COVID-19) in patients with cancer. Whether exercise lowers susceptibility or severity is not known. Methods: We identified 944 cancer patients from Memorial Sloan Kettering Cancer Center (mean age: 64; 85% female; 78% White) completing an exercise survey before receiving a confirmed positive or negative SARS-CoV-2 test. Exercise was defined as reporting moderate-intensity ≥5 days per week, ≥30 minutes/session or strenuous-intensity ≥3 days per week, ≥20 minutes/session. Multivariable logistic regression was used to determine the relationship between exercise and COVID-19 susceptibility and severity (i.e., composite of hospital admission or death events) with adjustment for clinical–epidemiologic covariates. Results: Twenty-four percent (230/944) of the overall cohort were diagnosed with COVID-19 and 35% (333/944) were exercisers. During a median follow-up of 10 months, 26% (156/611) of nonexercising patients were diagnosed with COVID-19 compared with 22% (74/333) of exercising patients. The adjusted OR for risk of COVID-19 was 0.65 [95% confidence interval (CI), 0.44–0.96, P = 0.03] for exercisers compared with nonexercisers. A total of 20% (47/230) of COVID-19 positive patients were hospitalized or died. No difference in the risk of severe COVID-19 as a function of exercise status was observed (P > 0.9). Conclusions: Exercise may reduce the risk of COVID-19 infection in patients with a history of cancer, but not its severity. Impact: This study provides the first data showing that exercise might lower the risk of COVID-19 in cancer patients, but further research is required.
Databáze: OpenAIRE
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