Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia
| Autor: | Hartmut Hengel, Armin J. Grau, E. Zimmermann, Werner Hacke, M. Zorn, M. Spiel, T. Fent, Matthias Maiwald, Florian Buggle, Egon Werle, Heiko Becher |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Ischemia Gastroenterology Brain Ischemia chemistry.chemical_compound Von Willebrand factor Risk Factors Internal medicine Humans Medicine Risk factor Stroke Aged Cerebrovascular Ischemia Aged 80 and over biology Factor VII business.industry Case-control study Bacterial Infections Odds ratio Middle Aged medicine.disease Cerebrovascular Disorders chemistry Virus Diseases Case-Control Studies Immunology biology.protein Female Neurology (clinical) business |
| Zdroj: | Neurology. 50:196-203 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | We performed a case-control study to investigate the role of recent infection as stroke risk factor and to identify pathogenetic pathways linking infection and stroke. We examined 166 consecutive patients with acute cerebrovascular ischemia and 166 patients hospitalized for nonvascular and noninflammatory neurologic diseases. Control subjects were individually matched to patients for sex, age, and season of admission. We assessed special biochemical parameters in subgroups of stroke patients with and without recent infection (n = 21) who were similar with respect to demographic and clinical parameters. Infection within the preceding week was a risk factor for cerebrovascular ischemia in univariate (odds ratio [OR] 3.1; 95% confidence interval (CI), 1.57 to 6.1) and age-adjusted multiple logistic regression analysis (OR 2.9; 95% CI, 1.31 to 6.4). The OR of recent infection and age were inversely related. Both bacterial and viral infection contributed to increased risk. Infection elevated the risk for cardioembolism and tended to increase the risk for arterioarterial embolism. Stroke patients with and without preceding infection were not different with respect to factor VII and factor VIII activity, fibrin monomer, fibrin D-dimer, von Willebrand factor, C4b-binding protein, protein S, anticardiolipin antibodies, interleukin-1 receptor antagonist, soluble tumor necrosis factor-α receptor, interleukin-6, interleukin-8, and neopterin. In conclusion, recent infection is an independent risk factor for acute cerebrovascular ischemia. Its role appears to be more important in younger age groups. The pathogenetic linkage between infection and stroke is still insufficiently understood. |
| Databáze: | OpenAIRE |
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