Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer
| Autor: | Thomas Winder, Michael Knauer, Alois Lang, Simone Rhomberg, Etienne Wenzl, Axel Mündlein, Alexander De Vries, Klaus Dirschmid, Heinz Drexel, Bernd L. Hartmann |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Male Cancer Research Pathology medicine.medical_specialty Genotype Colorectal cancer Kaplan-Meier Estimate medicine.disease_cause Disease-Free Survival Cohort Studies Internal medicine Carcinoma Medicine Humans Mutation frequency Survival rate Aged Mutation Oncogene business.industry Cancer General Medicine medicine.disease Survival Rate Genes ras Regression Analysis Female business Colorectal Neoplasms |
| Zdroj: | Oncology reports. 21(5) |
| ISSN: | 1021-335X |
| Popis: | A glycine to valine substitution at codon 12 (G12V) in Kirsten-Ras (K-Ras) gene has been associated with reduced overall survival in colorectal cancer patients; however, the effect of other K-Ras mutations than G12V still remains unclear. Therefore, we investigated the role of different K-Ras mutations on overall survival in a homogeneous, large patient cohort with standardized therapy and uniform analysis of K-Ras mutation status. The study included 342 patients with histopathologically proven colorectal cancer. Survival data were provided by the federal agency for statistics in Austria. Occurrence of K-Ras mutations at codons 12, 13 and 61 were determined by capillary sequencing. The overall K-Ras mutation frequency in carcinoma tissue was 28%. Carriers of the G12V mutation at the K-Ras gene showed a significantly decreased overall survival compared to carriers of the wild-type [HR=2.56 (1.15-5.69)]. Other mutations than G12V were associated with better overall survival compared to wild-type [HR=0.44 (0.2-0.99)]. In conclusion, for the first time, our study showed clearly that different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer. |
| Databáze: | OpenAIRE |
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