Rapid modulation of TRH and TRH-like peptide release in rat brain and peripheral tissues by prazosin
| Autor: | Albert Eugene Pekary, Albert Sattin, James Blood |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Physiology Thyrotropin-releasing hormone Biochemistry Rats Sprague-Dawley Stress Disorders Post-Traumatic Cellular and Molecular Neuroscience Norepinephrine Endocrinology Limbic system Internal medicine medicine Prazosin Animals Endocrine system Thyrotropin-Releasing Hormone Brain Rats Inbred Strains medicine.disease Hormones Pathophysiology Rats medicine.anatomical_structure Adrenergic alpha-1 Receptor Antagonists Psychology hormones hormone substitutes and hormone antagonists Anxiety disorder medicine.drug Hormone |
| Zdroj: | Peptides. 32:1666-1676 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/j.peptides.2011.06.012 |
| Popis: | Hyperresponsiveness to norepinephrine contributes to post-traumatic stress disorder (PTSD). Prazosin, a brain-active blocker of α1-adrenoceptors, originally used for the treatment of hypertension, has been reported to alleviate trauma nightmares, sleep disturbance and improve global clinical status in war veterans with PTSD. Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) may play a role in the pathophysiology and treatment of neuropsychiatric disorders such as major depression, and PTSD (an anxiety disorder). To investigate whether TRH or TRH-like peptides (pGlu-X-Pro-NH2, where “X” can be any amino acid residue) participate in the therapeutic effects of prazosin, male rats were injected with prazosin and these peptides then measured in brain and endocrine tissues. Prazosin stimulated TRH and TRH-like peptide release in those tissues with high α1-adrenoceptor levels suggesting that these peptides may play a role in the therapeutic effects of prazosin. |
| Databáze: | OpenAIRE |
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