An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon
| Autor: | Mitsunori Takase, Koji Yamauchi, Yutaka Saito, Tadao Kakizoe, Takahiro Kozu, Masumi Suzui, Jiegou Xu, David B. Alexander, Hirokazu Hamano, Masaaki Iigo, Daizo Saito, Hiroyuki Tsuda |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Placebo-controlled study Medicine (miscellaneous) Alpha interferon medicine.disease_cause Gastroenterology Human intestine Internal medicine Bovine lactoferrin medicine Ingestion TX341-641 Nutrition and Dietetics biology Nutrition. Foods and food supply Lactoferrin business.industry Cancer medicine.disease Ingestion of bovine lactoferrin Clinical trial Immunology biology.protein Human interferon alpha business Carcinogenesis geographic locations Food Science |
| Zdroj: | Journal of Functional Foods, Vol 10, Iss, Pp 305-317 (2014) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2014.06.028 |
| Popis: | Studies using animal models have demonstrated that ingestion of bovine lactoferrin (bLF) is able to induce cytokine expression in the intestine and inhibit carcinogenesis in the colon and other organs of experimental animals. Consequently, a clinical trial was conducted in the National Cancer Center Hospital, Tokyo, Japan to determine whether ingestion of bLF affected the growth of colorectal polyps in humans. The Tokyo-trial found that ingestion of 3.0 g bLF suppressed the growth of colorectal polyps and increased the level of serum human lactoferrin in participants 63 years old or younger. The present study is a complementary study to the Tokyo-trial to determine if a change in the expression of one or more cytokines could be detected in the colon of the Tokyo-trial participants after ingesting bLF. We found that daily ingestion of 3.0 g bLF promoted the expression of interferon alpha in the colon of the Tokyo-trial participants. |
| Databáze: | OpenAIRE |
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