On the crucial ventilatory setting adjustment from two- to one-lung ventilation
| Autor: | Roberta M. Lassance-Soares, Marcelo M. Morales, Patricia R. M. Rocco, Débora S. Faffe, Flavia Mazzoli-Rocha, Luiz Felipe M. Prota, Walter A. Zin, Giovanna Carvalho, Denise Momesso, Alysson R. Carvalho, Cristiane S. N. B. Garcia, Halina Cidrini Ferreira |
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| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Procollagen type-III VILI Physiology Neuroscience(all) Hypoxemia Positive-Pressure Respiration Parenchyma medicine Extracellular matrix expression Tidal Volume Animals Rats Wistar Tidal volume Lung Shear stress business.industry General Neuroscience Oxygenation Protective ventilator strategies respiratory system One lung ventilation respiratory tract diseases Rats Procollagen peptidase medicine.anatomical_structure Anesthesia Breathing Respiratory Mechanics medicine.symptom business Pulmonary Ventilation One-lung ventilation circulatory and respiratory physiology |
| Zdroj: | Respiratory physiologyneurobiology. 179(2-3) |
| ISSN: | 1878-1519 |
| Popis: | Lung mechanics, histology, oxygenation and type-III procollagen (PCIII) mRNA were studied aiming to evaluate the need to readjust ventilatory pattern when going from two- to one-lung ventilation (OLV). Wistar rats were assigned to three groups: the left lung was not ventilated while the right lung received: (1) tidal volume (V(T))=5 ml/kg and positive end-expiratory pressure (PEEP)=2 cm H(2)O (V5P2), (2) V(T)=10 ml/kg and PEEP=2 cm H(2)O (V10P2), and (3) V(T)=5 ml/kg and PEEP=5 cm H(2)O (V5P5). At 1-h ventilation, V5P2 showed hypoxemia, alveolar collapse and impaired lung function. Higher PEEP minimized these changes and prevented hypoxemia. Although high V(T) prevented hypoxemia and maintained a higher specific compliance than V5P2, a morphologically inhomogeneous parenchyma and higher PCIII expression resulted. In conclusion, the association of low V(T) and an adequate PEEP level could be useful to maintain arterial oxygenation without inducing a possible inflammatory/remodeling response. |
| Databáze: | OpenAIRE |
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