Ultrastaging of sentinel lymph nodes (SLNs) vs. non-SLNs in colorectal cancer—do we need both?
| Autor: | Nader Bassily, Peter S.-T. Ng, Weimin Liu, Aamir Ahsan, J. Badin, Maher Ghanem, S. Sirop, David Wiese, Ernesto B. Quiachon, Sukamal Saha, Brian Yestrepsky |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Colorectal cancer Sentinel lymph node H&E stain medicine Humans Lymph node Aged Neoplasm Staging Retrospective Studies Aged 80 and over Sentinel Lymph Node Biopsy business.industry Cancer General Medicine Middle Aged medicine.disease body regions medicine.anatomical_structure Immunohistochemistry Surgery Lymph Colorectal Neoplasms business Rectal disease |
| Zdroj: | The American Journal of Surgery. 199:354-358 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2009.08.032 |
| Popis: | The aim of this study to analyze whether ultrastaging of initially negative nonsentinel lymph nodes (non-SLNs) would increase nodal positivity in colon cancer and rectal cancer.After SLN mapping (SLNM), SLNs were ultrastaged by 4 hematoxylin and eosin and 1 immunohistochemistry sections. A blinded pathologist reexamined initially negative non-SLNs by 3 additional hematoxylin and eosin and 1 immunohistochemistry sections.In 156 colon cancer and 44 rectal cancer patients, 2,755 nodes were identified (494 SLNs and 2,261 non-SLNs). Metastases were detected in 20.9% of SLNs and 8.6% of non-SLNs (P.0001). After ultrastaging non-SLNs, only .58% became positive for metastases in 12 patients. Of these, 10 already had positive lymph nodes, hence no change of staging occurred. Ultrastaging upstaged only 2 of 200 patients (1%).The chance of finding additional metastases by ultrastaging of all non-SLNs is extremely low (1%) and of little benefit. |
| Databáze: | OpenAIRE |
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