Design, synthesis, and SAR analysis of novel selective σ1 ligands

Autor:	Caterina Zanette, Mariangela Urbano, Alice Pedrali, Christian Laggner, Maria Grazia Mamolo, Bernard Wuensch, Massimo Serra, Ornella Azzolina, Daniele Zampieri, Simona Collina, Dirk Schepmann, Daniela Rossi, Chiara Florio
Rok vydání:	2007
Předmět:	Models Molecular Magnetic Resonance Spectroscopy Chemical Phenomena Molecular model Stereochemistry Guinea Pigs Clinical Biochemistry Molecular Conformation Pharmaceutical Science In Vitro Techniques Biochemistry Chemical synthesis Radioligand Assay Structure-Activity Relationship Drug Discovery Radioligand Animals Receptors sigma Structure–activity relationship Molecular Biology Membranes Sigma-1 receptor Chemistry Physical Ligand Chemistry fungi Organic Chemistry Brain Sigma Affinities Drug Design bacteria Molecular Medicine Indicators and Reagents Chromatography Thin Layer
Zdroj:	Bioorganic & Medicinal Chemistry. 15:771-783
ISSN:	0968-0896
DOI:	10.1016/j.bmc.2006.10.048
Popis:	A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e1a278475e85547f1249d383945be1 https://doi.org/10.1016/j.bmc.2006.10.048 Zobrazit plný text záznamu Full Text from ScienceDirect