Biophysical mechanisms of electroconvulsive therapy-induced volume expansion in the medial temporal lobe: A longitudinal in vivo human imaging study
| Autor: | Ahmad Khatoun, Mathieu Vandenbulcke, Filip Bouckaert, Pascal Sienaert, Louise Emsell, Jeroen Blommaert, Myles Mc Laughlin, Maarten Laroy, Akihiro Takamiya, Zhi-De Deng, François-Laurent De Winter, Wim Van Paesschen, Ahmed Radwan, Stefan Sunaert, Jan Van den Stock |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) medicine.medical_treatment Biophysics Stimulation Neurosciences. Biological psychiatry. Neuropsychiatry Morphometry analysis behavioral disciplines and activities Article 050105 experimental psychology Temporal lobe White matter 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Cerebrospinal fluid Internal medicine mental disorders Electric field medicine Humans 0501 psychology and cognitive sciences Gray Matter Depression (differential diagnoses) Aged Aged 80 and over business.industry General Neuroscience 05 social sciences Brain Middle Aged Magnetic Resonance Imaging Seizure Temporal Lobe medicine.anatomical_structure Medial temporal lobe Brain size Cardiology Female Neurology (clinical) sense organs business 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Brain Stimulation, Vol 14, Iss 4, Pp 1038-1047 (2021) Brain stimulation |
| Popis: | BACKGROUND: Electroconvulsive therapy (ECT) applies electric currents to the brain to induce seizures for therapeutic purposes. ECT increases gray matter (GM) volume, predominantly in the medial temporal lobe (MTL). The contribution of induced seizures to this volume change remains unclear. METHODS: T1-weighted structural MRI was acquired from thirty patients with late-life depression (mean age 72.5 ± 7.9 years, 19 female), before and one week after one course of right unilateral ECT. Whole brain voxel-/deformation-/surface-based morphometry analyses were conducted to identify tissue-specific (GM, white matter: WM), and cerebrospinal fluid (CSF) and cerebral morphometry changes following ECT. Whole-brain voxel-wise electric field (EF) strength was estimated to investigate the association of EF distribution and regional brain volume change. The association between percentage volume change in the right MTL and ECT-related parameters (seizure duration, EF, and number of ECT sessions) was investigated using multiple regression. RESULTS: ECT induced widespread GM volume expansion with corresponding contraction in adjacent CSF compartments, and limited WM change. The regional EF was strongly correlated with the distance from the electrodes, but not with regional volume change. The largest volume expansion was identified in the right MTL, and this was correlated with the total seizure duration. CONCLUSIONS: Right unilateral ECT induces widespread, bilateral regional volume expansion and contraction, with the largest change in the right MTL. This dynamic volume change cannot be explained by the effect of electrical stimulation alone and is related to the cumulative effect of ECT-induced seizures. ispartof: BRAIN STIMULATION vol:14 issue:4 pages:1038-1047 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|