Nonsteroidal Anti-inflammatory Drugs Utilization Patterns and Risk of Adverse Events due to Drug-Drug Interactions among Elderly Patients: A Study from Jordan
| Autor: | Sayer I Al-Azzam, Zelal Jaber Kharaba, Anan S. Jarab, Ahmad Al-Azayzih, Rami H. Al-Rifai, Munther S. Alnajjar, Karem H. Alzoubi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty Gastrointestinal bleeding NSAIDs media_common.quotation_subject Pharmaceutical Science 030204 cardiovascular system & hematology ACEI Angiotensin converting enzyme inhibitors 030226 pharmacology & pharmacy digestive system Article 03 medical and health sciences Elderly 0302 clinical medicine Diclofenac Internal medicine medicine ARBS Angiotensin II Receptor Blockers NSAIDs Nonsteroidal Anti-inflammatory Drugs Adverse effect skin and connective tissue diseases GIT Gastrointestinal media_common Pharmacology Aspirin Jordan AKI Acute Kidney Injury COX-1 business.industry lcsh:RM1-950 Warfarin Co-prescribing COX-2 COX-1&2 Cyclooxygenase enzyme 1&2 Ibuprofen medicine.disease digestive system diseases lcsh:Therapeutics. Pharmacology business Ticagrelor CKD Chronic Kidney Disease medicine.drug |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 28, Iss 4, Pp 504-508 (2020) Saudi Pharmaceutical Journal : SPJ |
| ISSN: | 1319-0164 |
| Popis: | Background: Worldwide, the prescribing pattern of the Nonsteroidal Anti-inflammatory Drugs (NSAIDs) has increased. They are considered highly effective medications in controlling various conditions including inflammatory diseases. They are associated with various adverse effects including gastrointestinal bleeding and ulcer and renal toxicity though. These adverse effects are generally potentiated when NSAIDs are co-prescribed with other drugs that share similar adverse effects and toxicities. Developing severe side effects from NSAIDs is more prone among elderly patients. Hence, it is crucial to evaluate prescribing pattern of these agents to prevent/decrease the number of unwanted side effects caused by NSAIDs. Aim: The aim of this study is to assess the prescribing pattern of NSAIDs among elderly and the co-prescribing of NSAIDs and different interacting drugs, which could lead to more incidences of NSAIDs-induced toxicities among Jordanian elderly patients. Settings and Methodology: A multicenter retrospective study was performed during a three months period in Jordan. The study involves a total number of (n = 5916) elderly patient’s records obtained from Four governmental hospitals in Jordan. Results: A total number of (n = 20450) drugs were prescribed and dispensed for patient. NSAIDs drugs prescribing percentage was 10.3% of total medications number. Aspirin was the most commonly prescribed NSAIDs among patients (70.4%), followed by Diclofenac sodium in all dosage forms (25.1%) and oral Ibuprofen (3.1%. In addition, Aspirin was the highest NSAIDs co-prescribed with ACEI (e.g., Enalapril), ARBs (e.g. Candesartan and Losartan), Diuretics (Furosemide, Indapamide, Hydrochlorothiazide, Amiloride, and Spironolactone), Warfarin and antiplatelets (Clopidogreal and Ticagrelor) followed by Diclofenac and other NSAIDs. Conclusion: NSAIDs prescribing rate among elderly patients was high. Additionally the co-prescribing of NSAIDs especially Aspirin with other agents, which contributes to NSAIDs nephrotoxicity and gastrointestinal toxicity, were high. Strict measurements and action plans should be taken by prescribers to optimize the medical treatment in elderly through maximizing the benefits and decreasing the unwanted side effects. Keywords: NSAIDs, Elderly, Jordan, Co-prescribing, COX-1, COX-2, Aspirin |
| Databáze: | OpenAIRE |
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