Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease
| Autor: | Misun Hwang, Helmet T. Karim, Karen A. Nunley, Dana L. Tudorascu, Caterina Rosano, Trevor J. Orchard, Howard J. Aizenstein |
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| Rok vydání: | 2016 |
| Předmět: |
Cingulate cortex
medicine.medical_specialty Article Subject endocrine system diseases Endocrinology Diabetes and Metabolism Thalamus Inferior frontal gyrus 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology Brain mapping Cuneus 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Psychomotor learning Type 1 diabetes lcsh:RC648-665 business.industry Parietal lobe medicine.disease medicine.anatomical_structure Cardiology business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2016 (2016) |
| ISSN: | 2314-6753 2314-6745 |
| DOI: | 10.1155/2016/9571464 |
| Popis: | Slower psychomotor speed is very common in patients with type 1 diabetes mellitus (T1D), but the underlying mechanisms are not clear. We propose that hyperglycemia is associated with slower psychomotor speed via disruption of brain activation. Eighty-five adults (48% women, mean age: 49.0 years, mean duration: 40.8) with childhood onset T1D were recruited for this cross-sectional study. Median response time in seconds (longer = worse performance) and brain activation were measured while performing a psychomotor speed task. Exposure to hyperglycemia, measured as glycosylated hemoglobin A1c, was associated with longer response time and with higher activation in the inferior frontal gyrus and primary sensorimotor and dorsal cingulate cortex. Higher activation in inferior frontal gyrus, primary sensorimotor cortex, thalamus, and cuneus was related to longer response times; in contrast, higher activation in the superior parietal lobe was associated with shorter response times. Associations were independent of small vessel disease in the brain or other organs. In this group of middle-aged adults with T1D, the pathway linking chronic hyperglycemia with slower processing speed appears to include increased brain activation, but not small vessel disease. Activation in the superior parietal lobe may compensate for dysregulation in brain activation in the presence of hyperglycemia. |
| Databáze: | OpenAIRE |
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