PLEURAL EFFECTS OF INDIUM PHOSPHIDE IN B6C3F1 MICE: NONFIBROUS PARTICULATE INDUCED PLEURAL FIBROSIS

Autor:	Cassandra J. Shines, Daniel L. Morgan, Herman C. Price, Ronald W. Bousquet, Patrick J. Kirby, Jeffrey I. Everitt, Genie J. Taylor
Rok vydání:	2009
Předmět:	Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Time Factors Phosphines Pleural effusion Clinical Biochemistry Indium Article Mice Fibrosis Administration Inhalation medicine Animals Pleurisy Molecular Biology Inhalation exposure Inhalation Exposure Lung L-Lactate Dehydrogenase Inhalation medicine.diagnostic_test business.industry respiratory system medicine.disease respiratory tract diseases Pleural Effusion Disease Models Animal Bronchoalveolar lavage medicine.anatomical_structure Effusion Cytokines Pleura Particulate Matter business Bronchoalveolar Lavage Fluid
Zdroj:	Experimental Lung Research. 35:858-882
ISSN:	1521-0499 0190-2148
Popis:	The mechanism(s) by which chronic inhalation of indium phosphide (InP) particles causes pleural fibrosis is not known. Few studies of InP pleural toxicity have been conducted because of the challenges in conducting particulate inhalation exposures, and because the pleural lesions developed slowly over the 2-year inhalation study. The authors investigated whether InP (1 mg/kg) administered by a single oropharyngeal aspiration would cause pleural fibrosis in male B6C3F1 mice. By 28 days after treatment, protein and lactate dehydrogenase (LDH) were significantly increased in bronchoalveolar lavage fluid (BALF), but were unchanged in pleural lavage fluid (PLF). A pronounced pleural effusion characterized by significant increases in cytokines and a 3.7-fold increase in cell number was detected 28 days after InP treatment. Aspiration of soluble InCl(3) caused a similar delayed pleural effusion; however, other soluble metals, insoluble particles, and fibers did not. The effusion caused by InP was accompanied by areas of pleural thickening and inflammation at day 28, and by pleural fibrosis at day 98. Aspiration of InP produced pleural fibrosis that was histologically similar to lesions caused by chronic inhalation exposure, and in a shorter time period. This oropharyngeal aspiration model was used to provide an initial characterization of the progression of pleural lesions caused by InP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09db8294ef2d542d55f090cbc06b9100 https://doi.org/10.3109/01902140902980961 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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