Hepatocyte growth factor/Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathways
| Autor: | Yasuko Sakamoto, Naoki Terakawa, Masahiro Mitsunari, Satoru Tsukihara, Yumiko Iba, Sayako Horie, Tasuku Harada, Tomio Iwabe, Souichi Yoshida |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Stromal cell Endocrinology Diabetes and Metabolism Clinical Biochemistry Endometriosis Paracrine Communication Biology Biochemistry Paracrine signalling Endometrium Endocrinology Peritoneum Internal medicine medicine Ascitic Fluid Humans Receptor Autocrine signalling Cells Cultured Hepatocyte Growth Factor Biochemistry (medical) Proto-Oncogene Proteins c-met medicine.disease Urokinase-Type Plasminogen Activator Autocrine Communication medicine.anatomical_structure Enzyme Induction Hepatocyte growth factor Female Stromal Cells Cell Division medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 89(2) |
| ISSN: | 0021-972X |
| Popis: | Endometrial stromal cells reportedly have a role in the initial invasion of endometrial tissue into the peritoneum. Hepatocyte growth factor (HGF), which is a ligand for the c-met protooncogene product (Met), stimulates proliferation and invasion of a large number of cells. In this study we investigated the role of the HGF/Met system in the pathogenesis of endometriosis. HGF concentrations in the peritoneal fluid of patients with endometriosis were significantly higher than in those without endometriosis and correlated positively with revised American Society of Reproductive Medicine scores. We showed that the peritoneum and endometriotic stromal cells may be major sources of HGF in peritoneal fluid. Endometrial and endometriotic stromal cells expressed the Met receptor, which was activated by endogenous and exogenous HGF. HGF enhanced stromal cell proliferation and invasion. We also demonstrated that the HGF-stimulated stromal cell invasion was due in part to the induction of urokinase-type plasminogen activator, a member of the extracellular proteolysis system. In conclusion, the HGF/Met system is involved in the pathogenesis of endometriosis by promoting stromal cell proliferation and invasion of shed endometria and endometrial lesions via autocrine and paracrine pathways. |
| Databáze: | OpenAIRE |
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