Regional changes in myocardial acid production during ischemic arrest: a comparison of sanguineous and asanguineous cardioplegia
| Autor: | Peter C. Gherardi, Miguel Josa, Samar N. Assousa, Samer Y. Siouffi, Kenneth G. Warner, Shukri F. Khuri, Ernest M. Barsamian, Michael D. Butler, Assad J. Saad |
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| Rok vydání: | 1988 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Potassium Compounds Ischemia Coronary Disease Multiple dosing Canine heart Dogs Internal medicine medicine Carnivora Animals Cardioplegic Solutions Acidosis biology business.industry Myocardium Fissipedia Hydrogen-Ion Concentration medicine.disease biology.organism_classification Acid production Blood Anesthesia Time course Cardiology Heart Arrest Induced Potassium Surgery Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of thoracic surgery. 45(1) |
| ISSN: | 0003-4975 |
| Popis: | Regional differences in myocardial acid production have not been characterized during administration of either asanguineous or sanguineous cardioplegia. To investigate this, miniature glass pH electrodes were placed in the right ventricular (RV) myocardium, the left ventricular subendocardial (LV endo) region, and the subepicardial (LV epi) region in a canine model. Multiple doses of either blood cardioplegia (Group 1; N = 11) or crystalloid cardioplegia (Group 2; N = 11) were administered during 4 hours of aortic cross-clamping. The accumulation of hydrogen ions during the cross-clamp period was greater in Group 2 than Group 1 in the LV endo region (629 +/- 79 nm/L versus 66 +/- 31 nm/L; p less than 0.001), the LV epi region (623 +/- 66 nm/L versus 72 +/- 32 nm/L; p less than 0.001), and the RV myocardium (814 +/- 296 nm/L versus 150 +/- 54 nm/L; p less than 0.05). Within each group, the time course of myocardial pH and the accumulation of hydrogen ions did not differ among the LV endo region, LV epi region, and the RV myocardium (p = not significant). These data indicate that transmural and interventricular differences in myocardial pH and hydrogen ion accumulation are not produced in the vented, arrested canine heart. In addition, when compared with asanguineous cardioplegia, blood cardioplegia globally and transmurally reduces acid accumulation during ischemic arrest. |
| Databáze: | OpenAIRE |
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