Influence of serum paraoxonase polymorphism on serum lipids and apolipoproteins
Autor: | S. H. Teo, Shan S. Ratnam, John S. H. Tay, Ashim C. Roy, Nilmani Saha |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B Blood lipids Arylesterase chemistry.chemical_compound Polymorphism (computer science) Internal medicine Genetics medicine Humans Alleles Genetics (clinical) biology Triglyceride Aryldialkylphosphatase Chemistry Cholesterol Metabolism Lipids Phosphoric Monoester Hydrolases Enzyme assay Apolipoproteins Endocrinology biology.protein Regression Analysis Female lipids (amino acids peptides and proteins) |
Zdroj: | Clinical Genetics. 40:277-282 |
ISSN: | 1399-0004 0009-9163 |
Popis: | One hundred and sixty-three healthy Chinese subjects of both sexes were studied for serum paraoxonase (PON) polymorphism, and levels of lipids and apolipoproteins in order to examine effects of PON alleles on these parameters. The level of serum triglyceride was significantly higher in high activity allele (PON*B) compared with that in low activity allele (PON*A) in both sexes (P less than 0.01). The subjects with PON A had significantly higher LDL cholesterol (P less than 0.05) and lower Apo A-II and ApoB levels. The influence of serum paraoxonase on serum lipids was estimated further by Spearman's rank correlation. In the males, there was a significant negative correlation of serum paraoxonase activity with total (P less than 0.05) and LDL (P less than 0.01) cholesterol levels, and positive correlation with HDL cholesterol and Apo A-II levels (P less than 0.05). Serum paraoxonase activity had a high positive correlation with serum triglyceride levels in both sexes (P less than 0.001). Serum ApoB level had a positive correlation with the enzyme activity only in females (P less than 0.01). The allelic effect of PON on these parameters was studied by multiple regression analysis. The high activity allele (PON*B) was associated with higher serum triglyceride level (P less than 0.001) and ApoB (P less than 0.001), while it had lowering influence on total cholesterol (P less than 0.05) and LDL cholesterol (P less than 0.005) in men. The average allelic effect of PON was found to be about 22% for serum triglycerides, 11% for LDL cholesterol, 14% for Apo A-II and 19% for Apo B in the present study. This study suggests a possible significant role of serum paraoxonase alleles in the metabolism of serum lipids and apolipoproteins. |
Databáze: | OpenAIRE |
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