Blocking vicious cycle of cardiac dysfunction by external cardiopulmonary resuscitation is the key to rescue acute aluminium phosphide poisoning
| Autor: | Haixia Yan, Ting Wang, Jingjing Li, Daishan Jiang, Mingjun Yuan, Yunlan Ji, Zhongwei Huang, Mengqiu Li, Yayun Wang, Yan-bo Shen, Ding-shan Yuan, Yan Shen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Advanced and Specialized Nursing
Aluminium phosphide business.industry medicine.medical_treatment Organ dysfunction Metabolic acidosis General Medicine Pharmacology medicine.disease Zinc phosphide chemistry.chemical_compound chemistry Ventricular fibrillation Extracorporeal membrane oxygenation Medicine Radiology Nuclear Medicine and imaging Renal replacement therapy medicine.symptom Cardiology and Cardiovascular Medicine business Safety Research Aluminium phosphide poisoning |
| Zdroj: | Perfusion. 38:214-219 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/02676591211046868 |
| Popis: | Aluminium phosphide (ALP) and aluminium zinc phosphide (ZnP), the two main ingredients of fumigation drugs, are commonly used to kill insects or rodents in grain. When exposed to water, highly toxic phosphine gas is released and absorbed through the respiratory or digestive tract. Phosphine gas could non-selectively block cytochrome oxidase, inhibit electron transfer and suppress oxidative phosphorylation, leading to cellular hypoxia and organ dysfunction. The characteristic clinical manifestations are refractory shock and metabolic acidosis with high mortality. However, patients with ALP poisoning have a chance to be cured. Here, we report a case of oral ALP poisoning that was successfully treated by extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) during frequent ventricular fibrillation and cardiac dysfunction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|