Correlation between immunity from BCG and the morbidity and mortality of COVID-19
| Autor: | Sohan Anjana Kamburugamuwa, Dakshitha Wickramasinghe, N. Wickramasinghe, Dharmabandhu N. Samarasekera, Carukshi Arambepola |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Univariate analysis Tuberculosis Multivariate analysis lcsh:Arctic medicine. Tropical medicine business.industry lcsh:RC955-962 Incidence (epidemiology) Research Population Public Health Environmental and Occupational Health COVID-19 Fatality medicine.disease BCG vaccination Infectious Diseases Vaccination policy Immunity Tropical medicine medicine education business Demography |
| Zdroj: | Tropical Diseases, Travel Medicine and Vaccines Tropical Diseases, Travel Medicine and Vaccines, Vol 6, Iss 1, Pp 1-8 (2020) |
| DOI: | 10.21203/rs.3.rs-29399/v2 |
| Popis: | Background To investigate the association between parameters indicating immunity from BCG at country level (presence of BCG vaccination policy, BCG coverage, age-specific incidence of tuberculosis (TB)) and the morbidity and mortality of COVID-19. Methods Country-specific data for COVID-19 cases and deaths, demographic details, BCG coverage and policy, age-specific TB incidence and income level were obtained. The crude COVID-19 cases and deaths per 100,000 population were calculated and assessed against the parameters indicating immunity from BCG using linear regression analysis. Results Univariate analysis identified higher income level of a country to be significantly associated with COVID-19 cases (p p 65-years (Cases (rs = − 0.785,p = 0.0001)) and deaths (rs = − 0.647,p = 0.0001). Multivariate analysis identified the higher income level of a country and not having a universal BCG vaccination policy to affect the COVID-19 cases. The deaths were inversely affected by the presence of BCG vaccination policy and coverage; and positively by the TB incidence in patients > 65-years. Conclusion Significant inverse correlations observed between cases and deaths of COVID-19 and BCG related parameters highlights immunity from BCG as a likely explanation for the variation in COVID-19 across countries. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|