Acute renal disease in patients with ovarian peritoneal carcinomatosis treated with cytoreduction and HIPEC: the influence of surgery and the cytostatic agent used
| Autor: | José Gil, Carlos García-Palenciano, Felipe Alconchel, Álvaro Jesús Gómez-Ruiz, Alida González-Gil, A. Nieto, Jerónimo Martínez, Álvaro Navarro-Barrios, P.A. Cascales-Campos, Elena Gil-Gómez |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urology Renal function Hyperthermic Intraperitoneal Chemotherapy chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols medicine Humans Rifle Peritoneal Neoplasms Ovarian Neoplasms Chemotherapy Creatinine business.industry Acute kidney injury Cytoreduction Surgical Procedures Hyperthermia Induced Acute Kidney Injury medicine.disease Cytostatic Agents Combined Modality Therapy chemistry Cardiothoracic surgery Surgery Hyperthermic intraperitoneal chemotherapy Female Neoplasm Recurrence Local business Abdominal surgery |
| Zdroj: | Langenbeck's archives of surgery. 406(7) |
| ISSN: | 1435-2451 |
| Popis: | The main objective of this study was to evaluate the differences between cisplatin and paclitaxel in the development of postoperative renal toxicity, using as a reference the RIFLE (Risk, Injury, Insufficiency, Loss, and End-stage renal function) and AKIN (Acute Kidney Injury Network) criteria in patients with primary or recurrent ovarian cancer with peritoneal dissemination treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). One hundred fifty-two patients who were treated between December 2007 and June 2017 were analyzed. Patients who received previous platinum-based chemotherapy had higher baseline creatinine levels than those who had not (p = 0.05). A total of 11 (7.2%) and 4 (2.6%) patients developed an acute renal dysfunction (ARD) during the postoperative period of cytoreduction and HIPEC according to the RIFLE and AKI criteria respectively. RIFLE detects a higher rate of ARD due to different parameters such as GFR (7.2% versus 2.6%, p = 0.016). Performing ostomy (p = 0.007; OR: 39.320; 95% CI = 2.74–56.13) and using of cisplatin during HIPEC treatment (p = 0.017; OR = 13.619; 95% IC = 1.600–25.95) were factors independently related to a higher rate of ARD. ARD has a multifactorial origin. Cisplatin was associated with the development of a higher rate of ARD than paclitaxel. Diagnosis of ARD did not correlate with worse survival figures. |
| Databáze: | OpenAIRE |
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