Exhaled nitric oxide levels in childhood asthma: a more reliable indicator of asthma severity than lung function measurement?
| Autor: | Alessandro Bodini, Giorgio Piacentini, Ylenia Suzuki |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pharmacology
Budesonide Pathophysiology of asthma business.industry General Medicine respiratory system Airway obstruction medicine.disease respiratory tract diseases Pulmonary function testing Bronchial hyperresponsiveness Exhaled nitric oxide Immunology medicine Pharmacology (medical) Airway business Biotechnology medicine.drug Asthma |
| Zdroj: | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 13(4) |
| ISSN: | 1173-8804 |
| Popis: | The level of exhaled nitric oxide (NO) has been demonstrated to reflect the degree of airway inflammation in patients with asthma and to be related to the severity of asthma, as well as to the efficacy of treatment. In contrast, lung function tests provide information about airway volumes and flows reflecting the level of airway obstruction, but do not allow any direct information about the degree of airway inflammation. Several studies have evaluated the relationships between the level of airway inflammation assessed by exhaled NO and the levels of airway obstruction and/or bronchial hyperresponsiveness in asthmatic adults and children. These studies highlight the complex pathophysiology of asthma and suggest that exhaled NO may have a promising role in addition to lung function measurement in the evaluation of asthma severity in children. |
| Databáze: | OpenAIRE |
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