Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation
| Autor: | Barbara Carreira, Liane I.F. Moura, Helena F. Florindo, Anna Scomparin, Véronique Préat, Ronit Satchi-Fainaro, Carina Peres, Vanessa Sainz, Ana Luisa Silva, João Conniot, Ana I. Matos |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Inflammasomes Immunology 02 engineering and technology Biology Immunomodulation 03 medical and health sciences Cell pattern Immune system medicine Animals Humans Nanotechnology Immunology and Allergy Receptor Innate immune system business.industry Pattern recognition receptor Inflammasome Dendritic cell 021001 nanoscience & nanotechnology Immunity Innate Nanomedicine 030104 developmental biology Receptors Pattern Recognition Nanoparticles Immunotherapy Personalized medicine 0210 nano-technology business Neuroscience medicine.drug |
| Zdroj: | Seminars in Immunology. 34:3-24 |
| ISSN: | 1044-5323 |
| DOI: | 10.1016/j.smim.2017.09.003 |
| Popis: | Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medicine, the clinical translation of those nanoparticulate systems has still been impaired by the limited understanding on their interaction with complex biological systems. As a result, unexpected effects due to unpredicted interactions at biomaterial and biological interfaces have been underlying the biosafety concerns raised by the use of nanomaterials. This review explores the current knowledge on how nanoparticle (NP) physicochemical and surface properties determine their interactions with innate immune cells, with particular attention on the activation of pattern-recognition receptors and inflammasome. A critical perspective will additionally address the impact of biological systems on the effect of NP on immune cell activity at the molecular level. We will discuss how the understanding of the NP-innate immune cell interactions can significantly add into the clinical translation by guiding the design of nanomedicines with particular effect on targeted cells, thus improving their clinical efficacy while minimizing undesired but predictable toxicological effects. |
| Databáze: | OpenAIRE |
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