Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
| Autor: | Michel Angelo das Graças Silva Oliveira, Paula Melo de Abreu Vieira, André Talvani, Ana Beatriz Farias de Souza, Natália Alves de Matos, Guilherme de Paula Costa, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Sílvia Dantas Cangussú, Frank Silva Bezerra, Natália Pereira da Silva Araújo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Antioxidant Article Subject medicine.medical_treatment Flavonoid Pharmacology medicine.disease_cause Protective Agents General Biochemistry Genetics and Molecular Biology Antioxidants Cigarette Smoking 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Liver Function Tests medicine Cigarette smoke Animals heterocyclic compounds chemistry.chemical_classification General Immunology and Microbiology medicine.diagnostic_test business.industry Body Weight General Medicine Cigarette smoke exposure Mice Inbred C57BL Oxidative Stress 030104 developmental biology chemistry Liver 030220 oncology & carcinogenesis Medicine Quercetin Inflammation Mediators Liver function tests business Adjuvant Oxidative stress Biomarkers Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2020 (2020) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2020/2196207 |
| Popis: | Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |