Fever after bronchoscopy: serum procalcitonin enables early diagnosis of post-interventional bacterial infection
| Autor: | Peter Errhalt, Waltraud Riegler, Rosemarie Bauer, Jan Veres, Karin Meisinger, Sabin Handzhiev, Manuela Speiser, Klaus Hackner |
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| Rok vydání: | 2017 |
| Předmět: |
Calcitonin
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Fever of Unknown Origin Gastroenterology Procalcitonin Bronchoscopies Leukocyte Count 03 medical and health sciences 0302 clinical medicine Bronchoscopy Risk Factors Internal medicine medicine Humans Prospective Studies 030212 general & internal medicine Prospective cohort study Aged lcsh:RC705-779 medicine.diagnostic_test business.industry Area under the curve Bacterial Infections lcsh:Diseases of the respiratory system Middle Aged Confidence interval Surgery C-Reactive Protein Early Diagnosis ROC Curve 030228 respiratory system Absolute neutrophil count Female Airway business Bronchoalveolar Lavage Fluid Biomarkers Research Article |
| Zdroj: | BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-8 (2017) BMC Pulmonary Medicine |
| ISSN: | 1471-2466 |
| Popis: | Background The aim of this study was to differentiate unspecific and self-limiting fever after bronchoscopy from fever due to infection by using serum procalcitonin, C-reactive protein and neutrophil count. Furthermore, frequency of fever after bronchoscopy and procedures as possible risk factors were evaluated. Methods Three hundred and fourteen consecutive patients were included. All bronchoscopies were performed using jet-ventilation and general anesthesia. Patients were analyzed according to interventions performed during bronchoscopy and laboratory results. Microbiological assessment was done in patients who developed fever to prove or rule out a bacterial infection. Results Forty-four patients showed fever within 24 h following bronchoscopy (14%). A bacterial infection was proven in 11 patients with fever (3.5%). Procalcitonin, neutrophil count and C-reactive protein were significantly higher in patients with fever after bronchoscopy compared to non-fever patients. To predict bacterial infection in the receiver operating analysis, procalcitonin had the highest area under the curve (0.942; 95% confidence interval [CI], 0.768 to 1.000; p = |
| Databáze: | OpenAIRE |
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