Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury
| Autor: | Can Hakan Yildirim, Hatice Yagmurdur, Ali Bilge, Özgür Aksoy, Yasemen Adali, Aysu Hayriye Tezcan, Ömür Öztürk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
RD1-811 Nerve Crush Methylprednisolone Nerve Regenertaions Rats Sprague-Dawley 03 medical and health sciences Random Allocation 0302 clinical medicine Atrophy Oxidants Photochemical Ozone Peripheral Nerve Injuries Medicine Animals Inflammation Wound Healing business.industry Granulation tissue Recovery of Function Sciatic nerve injury Nerve injury medicine.disease Ozone therapy Sciatic Nerve Nerve Regeneration Rats Cellular infiltration medicine.anatomical_structure 030220 oncology & carcinogenesis Anesthesia Surgery Sciatic nerve medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.31 n.11 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 31, Issue: 11, Pages: 730-735, Published: NOV 2016 Acta Cirurgica Brasileira, Vol 31, Iss 11, Pp 730-735 (2016) |
| Popis: | PURPOSE: To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS: Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury. RESULTS: Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p |
| Databáze: | OpenAIRE |
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