Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism
| Autor: | Carlos Encinas, Julia Barsony, Hong Chen, Rene F. Chun, Songyang Ren, Martin Hewison, Lisa Nguyen, Shaoxing Wu, Mercedes A. Gacad, John S. Adams |
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| Rok vydání: | 2004 |
| Předmět: |
Vitamin
Vitamin D-binding protein Vitamin D-Binding Protein Endocrinology Diabetes and Metabolism Binding protein Clinical Biochemistry Cell Biology Biology Biochemistry Calbindin Calcitriol receptor Disease Outbreaks chemistry.chemical_compound Vitamin D binding Endocrinology chemistry Heat shock protein Vitamin D and neurology Animals Humans Molecular Medicine Vitamin D Molecular Biology Rickets |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. :461-465 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/j.jsbmb.2004.03.016 |
| Popis: | Using vitamin D-resistant New World primates as model of natural diversity for sterol/steroid action and metabolism, two families of novel intracellular vitamin D regulatory proteins have been discovered and their human homologs elucidated. The first family of proteins, heterogeneous nuclear ribonucleoproteins (hnRNPs), initially considered to function only as pre-mRNA-interacting proteins, have been demonstrated to be potent cis-acting, trans-dominant regulators of vitamin D hormone-driven gene transactivation. The second group of proteins bind 25-hydroxylated vitamin D metabolites. Their overexpression increases vitamin D receptor (VDR)-directed target gene expression. We found that these intracellular vitamin D binding proteins (IDBPs) are homologous to proteins in the heat shock protein-70 family. Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting. |
| Databáze: | OpenAIRE |
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