Regional tyrosine levels in rat brain after tyrosine administration
| Autor: | M. C. Morre, Richard J. Wurtman, Franz Hefti |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Telencephalon medicine.medical_specialty Hippocampus Endogeny Biology Increased tyrosine Cerebellum Internal medicine Limbic System medicine Animals Tissue Distribution Tyrosine Biological Psychiatry Tyrosinemia type II Medulla Oblongata Brain medicine.disease Rat brain Rats Cortex (botany) Psychiatry and Mental health Endocrinology Neurology Neurology (clinical) Catecholamine synthesis |
| Zdroj: | Journal of Neural Transmission. 49:45-50 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/bf01249188 |
| Popis: | Endogenous tyrosine concentrations varied two-fold among various rat brain regions, tending to be highest in brain stem structures. Administration of L-tyrosine (100 mg/kg) increased tyrosine concentrations in all brain areas; high relative increases were observed in areas with low initial tyrosine concentrations and vice versa, resulting in a more uniform distribution of tyrosine in the brain. Largest relative increases were observed in cortex and hippocampus. Tyrosine concentrations in all areas reached maximal levels 1 hour after tyrosine was given and declined gradually over the next 3 hours. The results suggest that tyrosine's effects on catecholamine synthesis and release might be amplified in cortex and hippocampus, where highest relative increases in tyrosine concentrations were observed. |
| Databáze: | OpenAIRE |
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