β-Adrenergic Receptors Regulate the Acquisition and Consolidation Phases of Aversive Memory Formation Through Distinct, Temporally Regulated Signaling Pathways
| Autor: | Jo Anna E. Klein, Mian Hou, Robert M. Sears, Joshua P. Johansen, David E. A. Bush, Joseph E. LeDoux, Hillary C. Schiff, Emily K. Smith |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine MAPK/ERK pathway Cell signaling MAP Kinase Signaling System Conditioning Classical Sensory system AMPA receptor Amygdala Developmental psychology Rats Sprague-Dawley Norepinephrine 03 medical and health sciences 0302 clinical medicine Memory Receptors Adrenergic beta medicine Animals Receptors AMPA Extracellular Signal-Regulated MAP Kinases Receptor Pharmacology Behavior Animal Basolateral Nuclear Complex Fear Rats Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Original Article Signal transduction Psychology Neuroscience 030217 neurology & neurosurgery Intracellular Signal Transduction |
| Zdroj: | Neuropsychopharmacology. 42:895-903 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/npp.2016.238 |
| Popis: | Memory formation requires the temporal coordination of molecular events and cellular processes following a learned event. During Pavlovian threat (fear) conditioning (PTC), sensory and neuromodulatory inputs converge on post-synaptic neurons within the lateral nucleus of the amygdala (LA). By activating an intracellular cascade of signaling molecules, these G-protein-coupled neuromodulatory receptors are capable of recruiting a diverse profile of plasticity-related proteins. Here we report that norepinephrine, through its actions on β-adrenergic receptors (βARs), modulates aversive memory formation following PTC through two molecularly and temporally distinct signaling mechanisms. Specifically, using behavioral pharmacology and biochemistry in adult rats, we determined that βAR activity during, but not after PTC training initiates the activation of two plasticity-related targets: AMPA receptors (AMPARs) for memory acquisition and short-term memory and extracellular regulated kinase (ERK) for consolidating the learned association into a long-term memory. These findings reveal that βAR activity during, but not following PTC sets in motion cascading molecular events for the acquisition (AMPARs) and subsequent consolidation (ERK) of learned associations. |
| Databáze: | OpenAIRE |
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