Efficacy of fipronil, amitraz and (S)-methoprene combination spot-on for dogs against adult dog fleas (Ctenocephalides canis, Curtis, 1826)
| Autor: | S. Yoon, Solange Vermot, Catherine Ollagnier, Martine Roques, Coralie Manavella, Michel Franc, L.G. Cramer, Emilie Bouhsira |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Insecticides Veterinary medicine Time Factors Toluidines Administration Topical Methoprene Biology Body weight medicine.disease_cause Beagle chemistry.chemical_compound Dogs Flea Infestations Animal science Infestation medicine Animals Dog Diseases Fipronil Amitraz Tick Control General Veterinary General Medicine Drug Combinations Treatment Outcome chemistry Pyrazoles Female Parasitology Ctenocephalides Ctenocephalides canis After treatment |
| Zdroj: | Veterinary Parasitology. 179:351-353 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2011.03.048 |
| Popis: | A novel spot-on formulation combining fipronil, amitraz and (S)-methoprene (CERTIFECT™, Merial Limited, GA, USA) was evaluated in adult Beagle dogs in a study to determine its adulticidal efficacy against the dog flea (Ctenocephalides canis, Curtis, 1826). Sixteen dogs were randomly allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once. Treatment consisted of applying a new combination formulation to deliver at least 6.7mg fipronil/kg body weight (bw), 8.0mg amitraz/kg bw, and 6.0mg (S)-methoprene/kg bw. The combination was designed to enhance the efficacy against ticks of the original fipronil/(S)-methoprene combination. Each dog was infested with 100 adult unfed dog fleas within 24h prior to treatment and then at weekly intervals for 8 weeks after treatment. At 24h after treatment or after each subsequent infestation, each dog was combed thoroughly to remove live fleas to be counted. A single treatment with CERTIFECT provided excellent knock-down of fleas within 24h after treatment and controlled re-infestations for up to 7 weeks (efficacy ≥96.5%, p |
| Databáze: | OpenAIRE |
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