Nimodipine can improve cerebral metabolism and outcome in patients with severe head trauma

Autor: H. M. Göksel, Adem Aslan, Mehmet Emin Buyukokuroglu, Mustafa Gurelik, Mustafa Cemek
Přispěvatelé: [Aslan, Adem] Afyon Kocatepe Univ, Fac Med, Dept Neurosurg, TR-03200 Afyon, Turkey -- [Gurelik, Mustafa -- Goksel, Hakan Murat] Cumhuriyet Univ, Fac Med, Dept Neurosurg, Sivas, Turkey -- [Cemek, Mustafa] Afyon Kocatepe Univ, Fac Sci & Arts, Dept Chem, Div Biochem, TR-03200 Afyon, Turkey -- [Buyukokuroglu, Mehmet Emin] Afyon Kocatepe Univ, Fac Med, Dept Pharmacol, TR-03200 Afyon, Turkey
Rok vydání: 2008
Předmět:
Zdroj: Pharmacological research. 59(2)
ISSN: 1043-6618
Popis: WOS: 000263708800006
PubMed ID: 18996202
In the present study, the effect of nimodipine was investigated in a patient with severe head trauma. Nimodipine was administered into the peripheral vein to prevent secondary neuronal damages in patients. The five patients in control group were treated according to the standard procedures without nimodipine. Other five patients in nimodipine group were treated with standard procedures plus nimodipine. Cerebral perfusion pressure (CPP), intracranial pressure (ICP), jugular venous oxygen saturation (SjvO(2)), jugular lactate and glucose levels were measured. Additionally, all patients were evaluated with Glascow outcome score (GOS) before discharge. It was found that CPP (p < 0.05) and SjvO(2) (p < 0.05)were significantly higher; but, ICP (p < 0.001),jugular lactate (p < 0.05) and jugular glucose (p < 0.05) were lower in nimodipine than that of control groups. Again, GOS values were significantly higher in nimodipine than that of control groups (p < 0.05). Results of this study revealed that nimodipine can improve cerebral metabolism and outcome in patient with severe head trauma. Thus, nimodipine may be considered as a protective agent against severe head trauma related neuronal injuries. (C) 2008 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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