Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson's Disease
Autor: | Sebastiaan P van Kessel, Sahar El Aidy |
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Přispěvatelé: | Host-Microbe Interactions, Molecular Immunology |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Levodopa Parkinson's disease Inflammation Review immune modulators Disease Gut flora Pathogenesis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Immune system medicine Animals Humans levodopa bacterial metabolites Gastrointestinal tract biology business.industry Parkinson Disease biology.organism_classification medicine.disease Gastrointestinal Microbiome 030104 developmental biology Immune System Immunology Parkinson’s disease Metabolome Dysbiosis Neurology (clinical) dopamine medicine.symptom Microbiota composition business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Journal of Parkinson's Disease, 9(2), S359-S370. IOS Press Journal of Parkinson's Disease |
ISSN: | 1877-7171 |
Popis: | Increasing evidence is supporting the hypothesis of α-synuclein pathology spreading from the gut to the brain although the exact etiology of Parkinson's disease (PD) is unknown. Furthermore, it has been proposed that inflammation, via the gastrointestinal tract, potentially through infections, may contribute to α-synuclein pathogenesis, and thus to the risk of developing PD. Recently, many studies have shown that PD patients have an altered microbiota composition compared to healthy controls. Inflammation in the gut might drive microbiota alterations or vice versa. Many studies focused on the detection of biomarkers of the etiology, onset, or progression of PD however also report metabolites from bacterial origin. These metabolites might reflect the bacterial composition and as well play an important role in immune homeostasis, ultimately affecting the progression of PD. Besides the bacterial metabolites, pharmacological treatment of PD might play a crucial role during the progression and thus treatment of the disease on the immune system. This review aims to establish a link between the microbial composition with the observed alterations of bacterial metabolites and their impact on the immune system, which could have influential effect in onset, progression and etiology of PD. |
Databáze: | OpenAIRE |
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