Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey
| Autor: | Nigar Sofiyeva, Fuat Demirkiran, Dogan Vatansever, Samet Topuz, Veysel Sal, Tayfun Gungor, Macit Arvas, Hasan Turan, Yavuz Salihoglu, Nedim Tokgozoglu, Cem Iyibozkurt, Hamdullah Sozen, Irem Demiral, Sinan Berkman, E Bengisu, Ilker Kahramanoglu, Burçin Salman Özgü, Tugan Bese, Mutlu Meydanli |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult Reoperation Cancer Research medicine.medical_specialty Epidemiology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Neoplasm Invasiveness 030212 general & internal medicine Stage (cooking) Survival rate Survival analysis Aged Neoplasm Staging Retrospective Studies Ovarian Neoplasms Univariate analysis business.industry Public Health Environmental and Occupational Health Retrospective cohort study Cytoreduction Surgical Procedures Middle Aged Debulking medicine.disease Prognosis Adenocarcinoma Mucinous Cystadenocarcinoma Serous Endometrial Neoplasms Log-rank test Survival Rate 030220 oncology & carcinogenesis Female Neoplasm Grading Neoplasm Recurrence Local Ovarian cancer business Adenocarcinoma Clear Cell Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 17(4) |
| ISSN: | 2476-762X |
| Popis: | Background The purpose of this study was to determine the benefit of tertiary cytoreductive surgery (TC) for secondary recurrent epithelial ovarian cancer (EOC), focusing on whether optimal cytoreduction has an impact on disease-free survival, and whether certain patient characteristics could identify ideal candidates for TC. Materials and methods Retrospective analysis of secondary recurrent EOC patients undergoing TC at three Turkish tertiary institutions from May 1997 to July 2014 was performed. All patients had previously received primary cytoreduction followed by intravenous platinum-based chemotherapy and secondary cytoreduction for first recurrence. Clinical and pathological data were obtained from the patients' medical records. Survival analysis was caried out using the Kaplan Meier method. Actuarial curves were compared by the two tailed Logrank test with a statistical significance level of 0.05. Results Median age of the patients was 49.6 years (range, 30-67) and thirty-eight (72%) had stage III-IV disease at initial diagnosis. Twenty six (49%) had optimal and 27 (51%) suboptimal cytoreduction during tertiary debulking surgery . Optimal initial cytoreduction, time to first recurrence, optimal secondary cytoreduction, time interval between secondary cytoreduction and secondary recurrence, size of recurrence, disease status at last follow-up were found to be significant risk factors to predict optimal TC. Optimal cytoreduction in initial and tertiary surgery and serum CA-125 level prior to TC were independent prognostic factors on univariate analysis. Conclusions Our results and a literature review clearly showed that maximal surgical effort should be made in TC, since patients undergoing optimal TC have a better survival. Thus, patients with secondary recurrent EOC in whom optimal cytoreduction can be achieved should be actively selected. |
| Databáze: | OpenAIRE |
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