Polymorphism of the SNP g. 1180 C>T in leptin gene and its association with growth traits and linear body measurement in Kebumen Ongole Grade cattle
| Autor: | Dyah Maharani, Akhmad Fathoni, Riyan Nugroho Aji, R. Choiri, Sumadi Sumadi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Population Single-nucleotide polymorphism Biology polymorphism leptin gene 03 medical and health sciences Internal medicine Genotype medicine SNP education 030304 developmental biology Genetic association lcsh:SF1-1100 0303 health sciences education.field_of_study lcsh:Veterinary medicine General Veterinary Leptin 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science Endocrinology Genetic marker identification lcsh:SF600-1100 Animal Science and Zoology lcsh:Animal culture Restriction fragment length polymorphism Kebumen Ongole Grade cattle |
| Zdroj: | Journal of the Indonesian Tropical Animal Agriculture, Vol 44, Iss 2, Pp 125-134 (2019) |
| ISSN: | 2460-6278 2087-8273 |
| Popis: | The aim of this study was to identify the polymorphism of leptin gene and its association with growth traits in Kebumen Ongole Grade cattle. One hundred blood samples were collected for molecular analysis. Polymorphism of the leptin gene was analyzed using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) with HpyCH4V restriction enzyme and DNA sequencing. Association analysis of the leptin gene with growth traits was analyzed by T-test. The results showed that SNP g. 1180 C>T was found in the population.The SNP changed amino acid from arginine to cysteine. The SNP was significantly associated with a high chest circumference at weaning age in animal having CC genotype (P T in the leptin gene is potential as genetic marker for growth traits in Kebumen Ongole Grade cattle. |
| Databáze: | OpenAIRE |
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