Secretive and proliferative tumor profile helps to select the best imaging technique to identify postoperative persistent or relapsing medullary thyroid cancer

Autor: Fausto Santeusanio, Gaetano Lombardi, Maria Grazia Chiofalo, Piero Ferolla, Annamaria Colao, Gabriella Angeletti, Franco Grimaldi, Antongiulio Faggiano, Corradina Caracò, Nicola Mozzillo, Luciano Pezzullo, Nicola Avenia
Přispěvatelé: Faggiano, Antongiulio, F., Grimaldi, L., Pezzullo, M. G., Chiofalo, C., Caracò, N., Mozzillo, A., Angeletti, F., Santeusanio, Lombardi, Gaetano, Colao, Annamaria, N., Avenia, P., Ferolla
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
Cancer Research
Pathology
Endocrinology
Diabetes and Metabolism
Scintigraphy
medullary thyroid cancer
Postoperative Complications
Endocrinology
Carcinoembryonic antigen
calcitonin
Receptors
Somatostatin
FDG-PET
Aged
80 and over
medicine.diagnostic_test
biology
Medullary thyroid cancer
Middle Aged
imaging technique
3-Iodobenzylguanidine
Oncology
Positron emission tomography
Carcinoma
Medullary
Lymphatic Metastasis
Predictive value of tests
ki67 index
somatostatin
Female
Adult
medicine.medical_specialty
Urology
Sensitivity and Specificity
Fluorodeoxyglucose F18
Predictive Value of Tests
medicine
Carcinoma
Humans
Thyroid Neoplasms
Aged
Retrospective Studies
business.industry
Calcitonin secretion
medicine.disease
Calcitonin
Positron-Emission Tomography
biology.protein
Neoplasm Recurrence
Local
Radiopharmaceuticals
business
Popis: In patients with postoperative persistent medullary thyroid cancer (MTC), the tumor detection rate is generally low for most of the imaging techniques now available. The aim of this study was to investigate if the clinico-biological profile of the tumor may indicate which imaging technique to perform in order to identify postoperative persistent or relapsing MTC foci. Thirty-five consecutive MTC patients with detectable and progressively increasing postoperative serum concentrations of calcitonin were enrolled in the study. The detection rates of 18F-deoxy-d-glucose (FDG)–positron emission tomography (PET), somatostatin receptor scintigraphy (SRS), and 131I-metaiodobenzylguanidine scintigraphy (MIBG) were compared in relation with calcitonin and carcinoembryonic antigen serum concentrations, Ki-67 score and results of conventional imaging techniques (CIT). FDG–PET positivity was significantly associated with calcitonin serum concentrations >400 pg/ml and Ki-67 score >2.0% (P800 pg/ml (PP2.0% suggests to perform a FDG–PET in addition to conventional imaging. Calcitonin secretion predicts both FDG–PET and SRS uptake but SRS positivity is generally found only in patients with well defined MTC lesions that are also detectable at the conventional imaging examination. MIBG outcome is not predicted by any clinico-biological factors here investigated.
Databáze: OpenAIRE
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