Lack of Absorption of Didanosine after Rectal Administration in Human Immunodeficiency Virus-Infected Patients
| Autor: | H. Jäger, Boris Rolinski, Johannes R. Bogner, Bernd H. Belohradsky, Uwe Wintergerst, E. Wolf, Adelbert A. Roscher, B. Sölder |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Anti-HIV Agents medicine.medical_treatment HIV Infections Gastroenterology Pharmacokinetics Administration Rectal Antacid Oral administration Internal medicine Blood plasma medicine Humans Pharmacology (medical) Child Didanosine Pharmacology Body surface area business.industry Liter Middle Aged Surgery Infectious Diseases Intestinal Absorption Area Under Curve Rectal administration business Half-Life medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.43.3.699 |
| Popis: | The feasibility of rectal administration of didanosine (DDI) was studied in six human immunodeficiency virus-infected patients. After oral intake of a DDI solution (100 mg/m 2 of body surface area) combined with an antacid (Maalox), pharmacokinetic parametric values were in accordance with previously published data; the mean ± standard deviation for terminal half-life was 59.5 ± 15.0 min, that for peak concentration was 5.2 ± 3.9 μmol/liter, and that for the area under the time-concentration curve (AUC) was 494 ± 412 min · μmol/liter. After rectal administration of a similarly prepared DDI solution (100 mg/m 2 of body surface area), plasma DDI levels were below the detection limit (0.1 μmol/liter) at all time points in five of the six patients, and in the remaining patient the AUC after rectal application was only 5% of that after oral administration. We conclude that oral administration of DDI cannot be easily replaced by rectal application. |
| Databáze: | OpenAIRE |
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