Total synthesis of scutellarin-7-O-Glucuronide
Autor: | Li-Ping Wu, Qian Liu, Gang Fang, Guo-Hong Zhang, Ya-Bo Duan, Song Wu, Jian-Mei Cui |
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Rok vydání: | 2005 |
Předmět: |
Pharmacology
chemistry.chemical_classification Chemistry Flavone derivatives Organic Chemistry Flavonoid Acetophenones Pharmaceutical Science Total synthesis General Medicine Uronic acid Asteraceae Flavones Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine Yield (chemistry) Drug Discovery Michael reaction Molecular Medicine Organic chemistry Hydrogenation Scutellarin-7-O-glucuronide |
Zdroj: | Journal of Asian Natural Products Research. 7:655-660 |
ISSN: | 1477-2213 1028-6020 |
Popis: | Scutellarin-7-O-glucuronide (1) has been synthesized from 2-hydroxyl-4,5,6-trimethoxyacetophenone through eight steps, including Michael addition, cyclization, hydrogenation, hydroxyl protection, deprotection, etc. The overall yield of 13% is much higher than that reported (0.6%) by L. Farkas, G. Mezey-Vàndor et al. in 1974. |
Databáze: | OpenAIRE |
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