Amitrole: Strain differences in morphological response of the liver following subchronic administration to mice
| Autor: | Hayashi Yoshiyuki, Ohhara Tadao, Toyama Motoko, Mori Satoru, Tochino Yoshihiro, Making Susumu, Takeuchi Yasuyoshi |
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| Rok vydání: | 1985 |
| Předmět: |
Pathology
medicine.medical_specialty Mice Inbred Strains Nod Severe fibrosis Biology Toxicology Nod mouse Preneoplastic lesion Mice Liver Neoplasms Experimental Species Specificity medicine Animals Amitrole NOD mice Immunity Cellular Hyperplasia Strain (chemistry) General Medicine Triazoles medicine.disease Liver Hepatocellular carcinoma Female Precancerous Conditions Hyperplastic nodules |
| Zdroj: | Toxicology Letters. 29:145-152 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(85)90035-9 |
| Popis: | Strain differences in the induction of hepatocellular preneoplastic lesions by amitrole were examined in NOD, ICR and DS mice. Amitrole was administered to mice in drinking water at a dose of 1% for 6 months. After 3 months, hyperplastic nodules (HN) and severe fibrosis were prominent in NOD mice but not in other strains. On examination at 6 months, both number and size of HN were greatest in the NOD strain. Furthermore, a hepatocellular carcinoma was found in a NOD mouse, suggesting that this strain is more susceptible to amitrole-induced hepatocarcinogenesis than are ICR or DS mice. |
| Databáze: | OpenAIRE |
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