Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon
| Autor: | John Stephen, Candy Dca, Daniel R, Timothy J. Mitchell, S. C. Haslam, Julian M. Ketley, D. W. Burdon |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Time Factors Colon Bacterial Toxins Clostridium difficile toxin A Clostridium difficile toxin B Ileum medicine.disease_cause Permeability Microbiology Enterotoxins medicine Animals Fluid accumulation Clostridium Dose-Response Relationship Drug business.industry Cytotoxins Toxin Chemistry Gastroenterology Rabbit (nuclear engineering) Clostridium difficile C difficile medicine.anatomical_structure Permeability (electromagnetism) Pediatrics Perinatology and Child Health Rabbits business Research Article |
| Zdroj: | Gut. 27:78-85 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.27.1.78 |
| Popis: | The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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