Fc receptor-mediated immunity against Bordetella pertussis
| Autor: | María Eugenia Rodríguez, Jeanette H. W. Leusen, Daniela Flavia Hozbor, Sandra M. M. Hellwig, W. L. van der Pol, J.G.J. van de Winkel |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Blood Bactericidal Activity
CD32 Bordetella pertussis Neutrophils Immunology Fc receptor Receptors Fc CD16 Pertussis toxin Microbiology Phagocytosis Immunity Humans Immunology and Allergy Opsonin Ciencias Exactas Respiratory Burst Immunity Cellular biology Receptors IgG Opsonin Proteins biology.organism_classification Antibodies Bacterial Immunoglobulin A Respiratory burst Immunoglobulin G biology.protein |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| Popis: | The relevance of specific Abs for the induction of cellular effector functions against Bordetella pertussis was studied. IgG-opsonized B. pertussis was efficiently phagocytosed by human polymorphonuclear leukocytes (PMN). This process was mediated by the PMN IgG receptors, FcγRIIa (CD32) and FcγRIIIb (CD16), working synergistically. Furthermore, these FcγR triggered efficient PMN respiratory burst activity and mediated transfer of B. pertussis to lysosomal compartments, ultimately resulting in reduced bacterial viability. Bacteria opsonized with IgA triggered similar PMN activation via FcαR (CD89). Simultaneous engagement of FcαRI and FcγR by B. pertussis resulted in increased phagocytosis rates, compared with responses induced by either isotype alone. These data provide new insights into host immune mechanisms against B. pertussis and document a crucial role for Ig-FcR interactions in immunity to this human pathogen. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
| Databáze: | OpenAIRE |
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