Neurocognitive and Hormonal Correlates of Voluntary Weight Loss in Humans
| Autor: | Stephen Stotland, Maria Zacchia, Mahsa Dadar, Kevin Larcher, Marie Lamarche, Maurice Larocque, Errol B. Marliss, Stephanie G. Scala, Selin Neseliler, Yashar Zeighami, Wen Hu, Alain Dagher |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Leptin Male medicine.medical_specialty Physiology media_common.quotation_subject Calorie restriction Overweight 03 medical and health sciences 0302 clinical medicine Cognition Weight loss Internal medicine Weight Loss Medicine Humans Obesity Molecular Biology media_common Caloric Restriction 2. Zero hunger business.industry Brain Appetite Cell Biology medicine.disease Ghrelin 030104 developmental biology Endocrinology Female medicine.symptom business Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Cell metabolism. 29(1) |
| ISSN: | 1932-7420 |
| Popis: | Summary Insufficient responses to hypocaloric diets have been attributed to hormonal adaptations that override self-control of food intake. We tested this hypothesis by measuring circulating energy-balance hormones and brain functional magnetic resonance imaging reactivity to food cues in 24 overweight/obese participants before, and 1 and 3 months after starting a calorie restriction diet. Increased activity and functional connectivity in prefrontal regions at month 1 correlated with weight loss at months 1 and 3. Weight loss was also correlated with increased plasma ghrelin and decreased leptin, and these changes were associated with food cue reactivity in reward-related brain regions. However, the reduction in leptin did not counteract weight loss; indeed, it was correlated with further weight loss at month 3. Activation in prefrontal regions associated with self-control could contribute to successful weight loss and maintenance. This work supports the role of higher-level cognitive brain function in body-weight regulation in humans. |
| Databáze: | OpenAIRE |
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