Hydroxyl free radical production during torsional phacoemulsification
| Autor: | Thomas Hebdon, Steven D. Aust, Jordan Humbert, Ramon Dimalanta |
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| Rok vydání: | 2010 |
| Předmět: |
Minerals
Phacoemulsification Materials science Hydroxyl Radical business.industry medicine.medical_treatment Acetates Sodium Chloride Torsional phacoemulsification Sensory Systems Drug Combinations Ophthalmology chemistry.chemical_compound Optics chemistry Spectrophotometry Malondialdehyde medicine Drainage Surgery Hydroxyl radical Therapeutic Irrigation business Biomedical engineering |
| Zdroj: | Journal of Cataract and Refractive Surgery. 36:2146-2149 |
| ISSN: | 0886-3350 |
| Popis: | Purpose To quantitate free radical generation during phacoemulsification using an ultrasonic phacoemulsification device that includes a torsional mode and evaluate tip designs specific to the torsional mode. Setting Chemistry and Biochemistry Department, Utah State University, Logan, Utah, USA. Design Experimental study. Methods Experiments were performed using the Infiniti Vision System and OZil handpiece. Hydroxyl radical concentrations in the aspirated irrigation solution during torsional phacoemulsification were quantitated as nanomolar malondialdehyde (nM MDA) and determined spectrophotometrically using the deoxyribose assay. Results The mean free radical production during phacoemulsification with torsional modality at 100% amplitude was 30.1 nM MDA ± 5.1 (SD) using a 0.9 mm 45-degree Kelman tapered ABS tip. With other tip designs intended for use with the torsional modality, free radical production was further reduced when fitted with the 0.9 mm 45-degree Kelman mini-flared ABS tip (13.2 ± 5.6 nM MDA) or the 0.9 mm 45-degree OZil-12 mini-flared ABS tip (14.3 ± 6.7 nM MDA). Although the measurements resulting from the use of the latter 2 tips were not statistically significantly different ( P ≈ .25), they were different from those of the tapered tip ( P Conclusions The MDA concentration in the aspirated irrigation solution using the torsional modality was approximately one half that reported for the handpiece’s longitudinal modality in a previous study using the same bent-tip design (Kelman tapered, P Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes. |
| Databáze: | OpenAIRE |
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