Can SCUBE1 be used to predict the early diagnosis, lesion volume and prognosis of acute ischemic stroke?
| Autor: | Hasan Ata Bolayir, Serkan Kapancik, Özlem Kayım Yıldız, Aslı Bolayır, Aydin Gulunay, Veysel Kenan Celik, Şeyda Figül Gökçe, Burhanettin Çiğdem |
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| Přispěvatelé: | [Bolayir, Asli -- Gokce, Seyda Figul -- Cigdem, Burhanettin -- Yildiz, Oztem Kayim] Sivas Cumhuriyet Univ, Med Fac, Neurol Dept, Sivas, Turkey -- [Bolayir, Hasan Ata] Sivas Numune State Hosp, Cardiol Dept, Sivas, Turkey -- [Gulunay, Aydin] Sivas Numune State Hosp, Neurol Dept, Sivas, Turkey -- [Celik, Veysel Kenan -- Kapancik, Serkan] Sivas Cumhuriyet Univ, Med Fac, Biochem Dept, Sivas, Turkey, Bolayir, Asli -- 0000-0001-6566-3751 |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
acute ischemic stroke medicine.medical_specialty SCUBE1 business.industry 030106 microbiology Biochemistry (medical) Clinical Biochemistry 030208 emergency & critical care medicine Inflammation Lesion volume Biochemistry 03 medical and health sciences 0302 clinical medicine inflammation Internal medicine platelet activation medicine Cardiology Platelet activation medicine.symptom business Molecular Biology Acute ischemic stroke |
| Zdroj: | Turkish Journal of Biochemistry. 44:16-24 |
| ISSN: | 1303-829X |
| DOI: | 10.1515/tjb-2018-0040 |
| Popis: | WOS: 000461427300003 Objective: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] is a novel biochemical marker. SCUBE1 is thought to play roles both in platelet activation and inflammation, which are important stages for the development of acute ischemic stroke (AIS). The purpose of our study was to determine the diagnostic and prognostic values and temporal change of plasma SCUBE1 levels in AIS patients. Materials and methods: Thirty-five patients diagnosed with AIS at the Cumhuriyet University Faculty of Medicine Neurology Department, between June and December 2017, and a control group of 35 healthy volunteers were included. Results: Median first day SCUBE1 value in the patient group was 97.51 ng/mL, and the median 7th day SCUBE1 value was 32.72 ng/mL. Median control group SCUBE1 value was 27.51 ng/mL. The first day SCUBE1 levels were significantly higher than the 7th day and the control group SCUBE1 levels (p = 0.001, p < 0.001, respectively). The ROC analysis showed that SCUBE1 levels above 68.8 ng/mL can be used as an indicator with high sensitivity and specificity for AIS diagnosis. Multivariate analysis revealed that the first day SCUBE1 had significant independent effects on development of AIS. In correlation analysis, plasma SCUBE1 levels showed a significantly positive correlation with lesion volume, NIHSS and MRS values (p < 0.01). Conclusion: First day plasma SCUBE1 values in AIS patients rised at significant levels compared to the control group. SCUBE1 could use both in the early diagnosis and prediction of prognosis and lesion volume of AIS patients. |
| Databáze: | OpenAIRE |
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