Ventral hippocampal projections to the medial prefrontal cortex regulate social memory
| Autor: | Holly Anne Robinson, Lucas Pozzo-Miller, Mary L. Phillips |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Social memory social memory Mouse Autism Spectrum Disorder Hippocampus Hippocampal formation Mice 0302 clinical medicine Rett syndrome Biology (General) Prefrontal cortex 0303 health sciences Behavior Animal General Neuroscience Pyramidal Cells musculoskeletal neural and ocular physiology General Medicine Temporal Lobe Autism spectrum disorder Knockout mouse behavior and behavior mechanisms Medicine psychological phenomena and processes Research Article QH301-705.5 Science Prefrontal Cortex autism Biology behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology MECP2 03 medical and health sciences Memory medicine Animals Humans Mecp2 030304 developmental biology General Immunology and Microbiology Recall medicine.disease 030104 developmental biology nervous system Autism Neuroscience ventral hippocampus 030217 neurology & neurosurgery medial prefrontal cortex |
| Zdroj: | eLife eLife, Vol 8 (2019) |
| DOI: | 10.1101/461533 |
| Popis: | SUMMARYInputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) have been implicated in several neuropsychiatric disorders. Here, we show that the long-range vHIP-mPFC projection is hyperactive in the Mecp2 knockout (KO) mouse model of the autism spectrum disorder Rett syndrome, which has deficits in social memory. Chronically mimicking vHIP-mPFC hyperexcitability in wild-type mice impaired social memory, whereas chronic inhibition of mPFC-projecting vHIP neurons in Mecp2 KO mice rescued social memory deficits; the extent of memory rescue was negatively correlated with the strength of vHIP input to the mPFC. Acute manipulations of the vHIP-mPFC projection also affected social memory in a specific and selective manner, suggesting that proper vHIP-mPFC signaling is necessary to recall social memories. In addition, we identified an altered vHIP-mPFC innervation pattern and increased synaptic strength onto layer 5 pyramidal neurons as contributing factors in aberrant vHIP-mPFC signaling in Mecp2 KO mice. |
| Databáze: | OpenAIRE |
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