Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer
| Autor: | Joe Y. Chang, H. Helen Liu, Roland L. Bassett, Zhongxing Liao, Isis Gayed, Ritsuko Komaki, Xiong Wei, Syed Wamique Yusuf |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Myocardial Ischemia Coronary artery disease Myocardial perfusion imaging Risk Factors Carcinoma Non-Small-Cell Lung Coronary Circulation medicine Humans Prospective Studies Radiation Injuries Lung cancer Prospective cohort study Aged Lung medicine.diagnostic_test business.industry Heart Septal Defects Lung Cancer Prognosis medicine.disease Combined Modality Therapy Small Cell Lung Carcinoma Radiation therapy Treatment Outcome medicine.anatomical_structure Chemoradiation Oncology Female Radiotherapy Intensity-Modulated Radiology Tomography X-Ray Computed business Nuclear medicine Perfusion Chemoradiotherapy |
| Zdroj: | Journal of Thoracic Oncology. 4(2):179-184 |
| ISSN: | 1556-0864 |
| DOI: | 10.1097/jto.0b013e3181990c46 |
| Popis: | Objective: We evaluated the prevalence of myocardial perfusion defects using myocardial perfusion imaging (MPI) after chemoradiation or radiation therapy (CRT/RT) in lung cancer patients and described their patterns in relation to tumor location. Methods: MPI in 44 patients who received RT for lung cancer and 44 control patients were compared. The two groups were comparable in risk factors for coronary artery disease. Data regarding tumor stage and location, interval between CRT/RT and MPI, and mean radiation dose to the heart was collected. The level of radiation delivered to the affected segments of the left ventricle versus the normal segments was compared using the isodose lines on the simulation computed tomography. Results: Considering all tumor locations, 8 patients (18%) demonstrated MPI defects after CRT/RT versus 9 (20%) in the controls. However, 7 of 18 patients (39%) with centrally located tumors in the CRT/RT group versus only 1 of 15 patients (7%) in the control group demonstrated MPI defect ( p = 0.04). The defects in the CRT/RT group were in the anterior and septal segments while the defects were in different segments in the controls. The median interval between end of RT and MPI was 12.3 months. The affected segments in the CRT/RT group received a mean radiation dose of 39.6 versus 11.4 Gy ( p = 0.003) to the normal segments. Conclusions: CRT/RT to centrally located lung tumors tends to cause anterior/septal MPI defects. Abnormal MPI segments in the CRT/RT group have received significantly higher radiation than normal segments. |
| Databáze: | OpenAIRE |
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