Somatostatin does not attenuate intestinal injury in dextran sodium sulphate-induced subacute colitis
| Autor: | M. A. C. Meijssen, Joanne Wilson, A. P. M. van Dijk, J. D. van Bergeijk, M. E. van Meeteren, C.J.A.M. Tak, Freek J. Zijlstra |
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| Přispěvatelé: | Internal Medicine |
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pancolitis experimental colitis medicine.medical_treatment Immunology Octreotide somatostatin Pharmacology dextran sulphate Mice Intestinal mucosa In vivo Internal medicine intestinal inflammation lcsh:Pathology medicine Animals Intestinal Mucosa Colitis neuropeptide Saline Acute colitis Mice Inbred BALB C Interleukin-6 business.industry Dextran Sulfate Cell Biology medicine.disease Interleukin-10 Somatostatin Endocrinology Female medicine.symptom business Research Article Interleukin-1 lcsh:RB1-214 medicine.drug |
| Zdroj: | Mediators of Inflammation, Vol 7, Iss 3, Pp 169-173 (1998) Mediators of Inflammation Mediators of Inflammation, 7, 169-173. Hindawi Publishing Corporation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | From severalin vitroandin vivostudies involvement of som atostatin (SMS) in intestinal inflammation emerge. Acute colitis induced in rats is attenuated by the long-acting SMS analogue octreotide. We studied the potential beneficial effect of SMS on non-acute experimental colitis. BALB/c mice received either saline, SMS-14 (36 or 120 μg daily) or octreotide (3 μg daily) subcutaneously delivered by implant osmotic pumps. A non-acute colitis was induced by administration of dextran sodium sulphate (DSS) 10% in drinking water during 7 days. DSS evoked a mild, superficial pancolitis, most characterized by mucosal ulceration and submucosal influx of neutrophils. Neither SMS-14 nor octreotide reduced mucosal inflammatory score or macroscopical disease activity, although reduction of intestinal levels of interleukin1 β (IL-1 β), IL-6 and IL-10 during DSS was augmented both by SMS and octreotide. A slight increase of neutrophil influx was seen during SMS administration in animals not exposed to DSS. In conclusion, SMS or its long-acting analogue did not reduce intestinal inflammation in non-acute DSS-induced colitis. According to the cytokine profile observed, SMS-14 and octreotide further diminished the reduction of intestinal macrophage and Th2 lymphocyte activity. |
| Databáze: | OpenAIRE |
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