Recommendations for Clinical Decision-making in Children with Type 1 Diabetes and Celiac Disease: Type 1 Diabetes and Celiac Disease Joint Working Group Report
| Autor: | Olcay Evliyaoğlu, Orhun Cig Taskin, Mehmet Nuri Ozbek, Beyza Eliuz Tipici, Gül Yeşiltepe Mutlu, Ömer Faruk Beşer, Firdevs Bas, Alev Keser, Mukadder Ayşe Selimoğlu, Zarife Kuloğu, Serra Muradoğlu, Aysun Bideci, Şükrü Hatun, Feyza Darendeliler, Nuray Uslu Kızılkan, Damla Gökşen, Yasar Dogan, Sema Aydogdu, Deniz Ertem, Tugba Koca, Zehra Aycan, Şenay Savaş Erdeve, Tuğba Gökçe, Buket Dalgic, Filiz Tutunculer |
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| Přispěvatelé: | Hatun, Şükrü, Dalgıç, Buket, Gökşen, Damla, Aydoğdu, Sema, Savaş Erdeve, Şenay, Kuloğu, Zarife, Doğan, Yaşar, Aycan, Zehra, Yeşiltepe Mutlu, Gül, Uslu Kızılkan, Nuray, Keser, Alev, Beşer, Ömer Faruk, Özbek, Mehmet Nuri, Bideci, Aysun, Ertem, Deniz, Evliyaoğlu, Olcay, Tipici, Beyza Eliuz, Gökçe, Tuğba, Muradoğlu, Serra, Taşkın, Orhun Çığ, Koca, Tuğba, Tütüncüler, Filiz, Baş, Firdevs, Darendeliler, Feyza, Selimoğlu, Mukadder Ayşe, Hatun, Şükrü (ORCID 0000-0003-1633-9570 & YÖK ID 153504), Mutlu, Gül Yeşiltepe (ORCID 0000-0003-3919-7763 & YÖK ID 153511), Kızılkan, Nuray Uslu (ORCID 0000-0002-1098-9604 & YÖK ID 221274), Taşkın, Orhun Çığ (ORCID 0000-0002-6668-3006 & YÖK ID 166686), Dalgıç, B., Gökşen, D., Aydoğdu, S., Savaş, Erdeve Ş., Kuloğu, Z., Doğan, Y., Aycan, Z., Keser, A., Beşer, Ö.F., Özbek, M.N., Bideci, A., Ertem, D., Evliyaoğlu, O., Eliüz Tipici, B., Gökçe, T., Muradoğlu, S., Koca, T., Tütüncüler, F., Baş, F., Darendeliler, F., Selimoğlu, M.A., Koç University Hospital, School of Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Joint working Pediatric endocrinology Endocrinology Diabetes and Metabolism Clinical Decision-Making Disease Anti-tissue transglutaminase-IgA Celiac disease Children Type 1 diabetes Endocrinology Clinical decision making Genetic predisposition Medicine Humans Child Autoantibodies Transglutaminases medicine.diagnostic_test business.industry Gold standard medicine.disease Endoscopy Immunoglobulin A Diabetes Mellitus Type 1 Endocrinology and metabolism Pediatrics Perinatology and Child Health anti-tissue transglutaminase-IgA Type 1 Diabetes business |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| Popis: | It is well-known that in children with type 1 diabetes (T1D), the frequency of Celiac disease (CD) is increased due to mechanisms which are not fully elucidated but include autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is the gold standard for diagnosis, avoiding unnecessary endoscopy is crucial. Therefore, for both clinicians and patients’ families, the diagnosis of CD remains challenging. In light of this, a joint working group, the Type 1 Diabetes and Celiac Disease Joint Working Group, was convened, with the aim of reporting institutional data and reviewing current international guidelines, in order to provide a framework for clinicians. Several controversial issues were discussed: For CD screening in children with T1D, regardless of age, it is recommended to measure tissue transglutaminase-immunoglobulin A (tTG-IgA) and/or endomysial-IgA antibody due to their high sensitivity and specificity. However, the decision-making process based on tTG-IgA titer in children with T1D is still debated, since tTG-IgA titers may fluctuate in children with T1D. Moreover, seronegativity may occur spontaneously. The authors’ own data showed that most of the cases who have biopsy-proven CD had tTG-IgA levels 7-10 times above the upper limit. The decision for endoscopy based solely on tTG-IgA levels should be avoided, except in cases where tTG-IgA levels are seven times and above the upper limit. A closer collaboration should be built between divisions of pediatric endocrinology and gastroenterology in terms of screening, diagnosis and follow-up of children with T1D and suspicious CD. NA |
| Databáze: | OpenAIRE |
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