Anti-α chain monoclonal antibodies of equine MHC class-II antigens: applications to equine infectious anaemia
| Autor: | J. C. Monier, S. Bendali-Ahcène, M. Fontaine, Jean-Luc Cadoré |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.drug_class
CD8 Antigens Blotting Western Population Cell Fluorescent Antibody Technique Thymus Gland Cross Reactions Lymphocyte Activation Major histocompatibility complex Monoclonal antibody Equine infectious anaemia Mice Antigen Leukocytes medicine Animals Horses education Mice Inbred BALB C education.field_of_study General Veterinary biology Histocompatibility Antigens Class II Antibodies Monoclonal Flow Cytometry Immunohistochemistry Virology Molecular Weight Equine Infectious Anemia Phenotype medicine.anatomical_structure CD4 Antigens Immunology biology.protein Electrophoresis Polyacrylamide Gel Horse Diseases Lymph Nodes CD8 |
| Zdroj: | Research in Veterinary Science. 62:99-104 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/s0034-5288(97)90128-4 |
| Popis: | This paper describes the characteristics of a monoclonal antibody (mAb), 6B I1 C3, that recognises most equine monocytic cells, as well as B- and T-lymphocytes. The T CD4+ and T CD8+ of this latter population are also stained by the 6B 11 C3 mAb. On the basis of the distribution of membrane antigens on these cell populations, and of immunohistochemistry results, this mAb appears to be an anti-equine class-II major histocompatibility complex ( mhc ) antigen. In horses, the hyperexpression of the MHC class-II antigen on T cells is an indication of activated lymphocytes. A decrease in the percentage of lymphocytes stained by 6B 11 C3 was observed in horses with persistent equine infectious anaemia. |
| Databáze: | OpenAIRE |
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