Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load
| Autor: | Maryam Mohammadi, Ralph N. Martins, Preeti Dave, Prita R. Asih, David B. Lovejoy, Steve Pedrini, Henrik Zetterberg, Kevin Taddei, Kaikai Shen, Hamid R. Sohrabi, Nicholas J. Ashton, Pratishtha Chatterjee, Cintia B. Dias, Tejal M. Shah, Kathryn Goozee, Kaj Blennow, Abdul Hye |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty positron emission tomography amyloid deposits Amyloid Ferroportin Neocortex Logistic regression Pathogenesis 03 medical and health sciences Cognition 0302 clinical medicine Hepcidins Hepcidin Internal medicine medicine Humans Aged Aged 80 and over Amyloid beta-Peptides biology Receiver operating characteristic business.industry General Neuroscience Area under the curve iron dyshomeostasis General Medicine Peptide Fragments Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies 030104 developmental biology Endocrinology Positron-Emission Tomography biology.protein Female hepcidin Geriatrics and Gerontology business Alzheimer’s disease Biomarkers 030217 neurology & neurosurgery Research Article Hormone |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background/Objective: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation. Given that iron dyshomeostasis has been observed in Alzheimer’s disease (AD) together with elevated serum hepcidin levels, the current study examined whether elevated serum hepcidin levels are an early event in AD pathogenesis by measuring the hormone in cognitively normal older adults at risk of AD, based on high neocortical amyloid-β load (NAL). Methods: Serum hepcidin levels in cognitively normal participants (n = 100) aged between 65–90 years were measured using ELISA. To evaluate NAL, all participants underwent 18F-florbetaben positron emission tomography. A standard uptake value ratio (SUVR) |
| Databáze: | OpenAIRE |
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