Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness - A randomized sham-controlled exposure study
| Autor: | Bryan Hellack, Thomas A. J. Kuhlbusch, Birgitta Sasse, Samir Shinnawi, Heinz Kaminski, Vanessa J. Soppa, Barbara Hoffmann, Ulrich Quass, Roel P. F. Schins, Frauke Hennig |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Materials science Particle number Pulse Wave Analysis Adolescent Medizin 010501 environmental sciences 01 natural sciences 03 medical and health sciences Young Adult 0302 clinical medicine Indoor air quality Vascular Stiffness Linear regression Ultrafine particle medicine Humans 030212 general & internal medicine Cooking Particle Size Pulse wave velocity 0105 earth and related environmental sciences Air Pollutants Public Health Environmental and Occupational Health Environmental Exposure Middle Aged medicine.disease Healthy Volunteers Air Pollution Indoor Arterial stiffness Particle Female Particulate Matter Biomedical engineering |
| Zdroj: | International journal of hygiene and environmental health. 222(8) |
| ISSN: | 1618-131X |
| Popis: | Objectives Particulate air pollution is linked to adverse cardiovascular effects, including arterial stiffness. The aim of the study was to investigate the effect of short-term exposure to indoor fine and ultrafine particles on augmentation index (AIx), augmentation pressure (AP), and pulse wave velocity (PWV), early signs of vascular damage. Methods We analyzed the association of particle emissions from typical indoor sources (candle burning - CB, toasting bread - TB, and frying sausages - FS) with changes in pulse wave analysis indices in 55 healthy adults in a randomized cross-over controlled exposure study. Particle mass concentration (PMC), size-specific particle number concentration (PNC) and lung-deposited particle surface area concentration (PSC) were measured during the 2 h exposure. AIx and AP were measured before, directly, 2, 4 and 24 h after exposure. PWV was measured directly and 24 h after exposure. We performed multiple mixed linear regression analyses of different particle metrics and AIx, AP and PWV. Results The highest mean PMC was observed during FS reaching a maximum of 210 μg/m3 PM10. The maximal PNC for UFP Conclusions Our study indicates effects of indoor exposure to fine and ultrafine particles on systemic arterial stiffness indices that depend on the indoor source as well as on particle metric. Differences in size-specific physical characteristics of source-specific particles might account for these differential effects. We did not observe clear and stable associations of indoor particle exposure and PWV. |
| Databáze: | OpenAIRE |
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