Granulocytic sarcoma of the brain in a patient with acute myeloid leukemia
| Autor: | Darinka V. Bošković, Milica R. Čolović, Svetlana Ivanović, Vesna Cemerikic-Martinovic, Milica Skender-Gazibara, Natasa Colovic, Tatjana Terzic |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology medicine.medical_specialty Brain Neoplasms business.industry Myeloid leukemia Chromosomal translocation General Medicine Middle Aged medicine.disease Temporal Lobe Frontal Lobe Basophilic Leukemia Myeloid Acute Haematopoiesis Leukemia medicine.anatomical_structure medicine Humans Immunohistochemistry Sarcoma Bone marrow Sarcoma Myeloid business |
| Zdroj: | Acta chirurgica Iugoslavica. 51:129-131 |
| ISSN: | 2406-0887 0354-950X |
| DOI: | 10.2298/aci0403129c |
| Popis: | Granulocytic sarcoma is extramedullary tumor composed of immature leukemic cells most frequently located in close proximity to bone, but it also can be found in the skin, breast, gastrointesti- nal tract, ovaries and brain. Granulocytic sarco- ma may arise during the course of leukemia or precede its development in the bone marrow. The majority of reported cases of granulocytic sarcomas in acute myleoid leukemia have chromosome translocation t(8;21). We report a 46-year-old man with acute myeloid leukemia, type M2 involving the marrow and peripheral blood and chromosome t(8;21) who developed granulocytic sarcoma in the brain, as a first manifestation of relapse 6 months after complete remission was achieved. During a neurosurgical operation a cortically located tumor (3.5x5 cm) in the brain was partially removed. Histology showed tumor consisted of homogenous infiltrate of blasts, admixed with more mature haematopoietic cells. The blasts have large round to oval nuclei, delicate chromatin, one or more small well-defined nucleoli and scant basophilic cytoplasm. Immunohistochemistry showed that blast cells were myeloperoxidase positive, confirming the diagnosis of myeloblastic sarcoma in the brain. The patient died two days after surgery. |
| Databáze: | OpenAIRE |
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