Tin-absorbed resin for the preparation of 99mTc-radiopharmaceuticals: stable complex of 99mTc-bleomycin
| Autor: | Hideo Saji, Kanji Torizuka, Akira Yokoyama, Teruo Odori, Kazuko Horiuchi, Yasuhisa Fujibayashi, Hisashi Tanaka, Rikushi Morita |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Reducing agent
Inorganic chemistry chemistry.chemical_element Technetium Chloride Bleomycin Mice Adsorption medicine Animals Technology Pharmaceutical Radiology Nuclear Medicine and imaging Carcinoma Ehrlich Tumor Radionuclide Imaging Radiation Ligand Chemical state Nuclear Energy and Engineering chemistry Tin Isotope Labeling SN2 reaction Ion Exchange Resins Reagent Kits Diagnostic Oxidation-Reduction medicine.drug |
| Zdroj: | The International journal of applied radiation and isotopes. 32(1) |
| ISSN: | 0020-708X |
| Popis: | Stannous chloride has been the reducing agent of choice for the preparation of 99mTc-containing radiopharmaceuticals, whose effective chemical form is considered to be a complex, or complexes, of the reduced form of technetium. Labeling of 99mTc-BLM, a technetium complex of bleomycin, has been reported previously, but a stable complex for adequate clinical evaluation has been difficult to obtain. The main role of stannous chloride is as reducing agent but, depending upon the amount and the chemical state of the stannous ion, other phenomena have been detected and further implications for the incorporation of 99mTc into a ligand are discussed. However, the stannous ion adsorbed onto a cationic exchange resin showed specific characteristics allowing the preparation of a stable complex of BLM, considered to be a mononuclear complex. The usefulness of this tin-adsorbed resin (Sn-resin) as an efficient device (kit) for the controlled delivery of Sn2+ ion, permitting the simple preparation of a stable complex with good reproducibility in Nuclear Medicine facilities is presented. |
| Databáze: | OpenAIRE |
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